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Regenerative Medicine

Regenerative Medicine Therapies

Regenerative medicine is an interdisciplinary field that applies engineering and life science principles to promote regeneration and healing.  This field is nearly two decades old, and amazingly, it appears to offer the potential to restore injured tissues, improve healing and at some future point, repair whole organs.  Whether with stem cell injections (MSC) or immune modulation via molecules or proteins such as PRP, A-2 Macroglobulin, amniotic tissue membrane, exosomes, or other growth factors, the goal is to enhance the intrinsic regenerative capacity of your own body to repair and heal. 

Joints of interest for stem cell injections:  

  • Shoulders
  • Hips
  • Knees
  • Ankles
  • Elbows
  • Spine
  • Neck
  • Wrists & hands

Regenerative therapies, including stem cell therapies hold great promise for all of us and while some are FDA approved, others are not.  This field is exploding, and while it is impossible to be aware of all ongoing research in this area, as your health and wellness physician, I pledge to the best of my ability to provide you with the information you need to be comfortable that you have been informed as to the risks, potential benefits, and alternatives for such treatment.

Stem Cell Therapy FAQ's

Regenerative medicine is an interdisciplinary field that applies engineering and life science principles to promote regeneration that can potentially restore diseased and injured tissues and whole organs.

Regenerative medicine is a branch of translational research in tissue engineering and molecular biology, which deals with the “process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function”.

Stem cells are the construction workers of the body’s repair mechanism. Their role is to maintain and initiate the healing of damaged tissue and replenish dying or damaged cells. Stem cells find the damaged tissue and have the potential to initiate repair or regeneration. Mesenchymal stem cells contain specialized proteins, which are thought to reduce inflammation and promote healing, including growth factors which support cell and tissue regeneration.

DV360 works with Greyledge Technologies to produce PRP (Platelet Rich Plasma) and BMC (Bone Marrow Concentrate). Greyledge is an industry leader in isolating and concentrating a patient’s own cells (autologous cells) from blood or bone marrow to create the highest quality implantable therapeutics available to ensure safety and maximize potential for successful treatment.

  • Platelet Rich Plasma (PRP)
  • Bone Marrow Concentrate (BMC)

Signature Biologics utilizes their proprietary Signature Process to produce placental-derived tissue products. The Signature Process consists of advanced standardized processing techniques that preserve the tissue integrity and growth factors to potentially enhance the body’s natural healing ability. This attention to detail pioneers our future into cellular and acellular products, relying on decades of biologics leadership with ongoing participation in the allogeneic stem cell Investigational New Drug (IND) studies. 

Signature Cord Prime™ Receives Investigational New Drug (IND) Approval from FDA for Phase 1 Study in Patients with Symptomatic Osteoarthritis of the Knee. (


  • Low risk.
  • Minimally invasive. Therapies are minimally invasive, in contrast to traditional treatments such as joint replacement. The outpatient procedure is performed in approximately 30 minutes, and patients generally do not require any pain medication following the procedure..
  • Avoiding surgery. Therapies may be utilized to avoid or delay orthopedic surgery, including knee replacements, arthroscopy, spinal fusions, or lumbar disc replacements.
  • Supports the body’s ability to rebuild your own healthy tissue.
  • Convenience. When timing your stem cell procedure, there is no need to consider the demanding recovery typically experienced with surgery.
  • Fast recovery. Activity restrictions following the procedure are minimal. Patients can return to work in 1 day and perform more strenuous activities within 1-3 weeks. 
  • Significant pain reduction and increased mobility have been reported.

The recovery time following the procedure is very quick – usually within 15-30 minutes.  If you have taken a medication to help you feel more comfortable during the procedure, we request that you receive a ride to and from the facility.  You can be back at work the day following your procedure.

The Regenerative process begins right away with noticeable improvement usually within the first 3 months, continuing up to 1 year. Some patients request a follow-up treatment about 4 -12 weeks after the initial injection. This booster provides additional growth factors and/or cells to support the ongoing healing process.

Dr. Robert Bulger will help determine whether or not you are a candidate for this therapy by administering a physical examination and carefully reviewing the appropriate imaging (x-ray and/or MRI), along with taking the additional time to consult with a musculoskeletal specialist on each individual case.

As we age, our bodies have a harder time maintaining healthy tissues and function. We may experience a longer healing time, increased inflammation, a declining chemical environment, and cell aging causing healthy tissues to become dysfunctional. Regenerative medicine therapies are utilized to promote the body’s ability to repair, reconstruct, replace, or supplement the patient’s cells or tissues. The cells promote the neutralization of inflammation and may accelerate healing. With the potential to regenerate injured cartilage tissue, tendons, bone, muscle, ligaments and vertebral disc cartilage, the cell therapies facilitate the stimulation of your body’s own natural healing processes.

The purpose of regenerative medicine is to support the restoration of healthy cells, promoting the repair response of diseased, dysfunctional, or injured tissue.

  • Promising alternative to surgery, promoting your bodies’ natural ability to heal itself.
  • Promote repair in different kinds of cells.
  • Drug-free way to treat pain. Cortisone offers temporary relief but may cause long-term side effects while regenerative medicine may actually restore degenerated tissue, resulting in lasting pain relief.

Yes, regenerative medicine is safe. The risks of stem cell therapy are minimal and often misunderstood. 

  • There is a minute risk for infection at the injection site.
  • These cells have a short life-span and need to survive long enough to biologically seek out the damaged area to make an impact. This cannot be guaranteed and may require repeated treatments which still may fail to improve your condition.
  • Research is ongoing. While a great deal is known about stem cells and their byproducts, the precise mechanism by which these cells or their byproducts work is not fully understood. Outstanding results are reported for many but not all patients. 
  • When utilizing allogeneic cells, your body’s own immune system may become activated, causing an allergic reaction which can be as mild as a rash treated with some cortisone, but rarely can be serious and require hospitalization. Typically these reactions are immediate, but can be delayed.
  • A yet unknown syndrome or reaction, including death, as a result of allogeneic stem cell transplantation cannot be ruled out as a possible consequential result of this procedure.

A patient’s specific procedure will be decided upon during a one-on-one consultation. Below is a brief general guideline of what to expect.

  • One on one consultation with Dr. Robert Bulger, ABMS certified in Pain Management.
  • Review of appropriate history and imaging studies.
  • Dr. Bulger will also review your imaging study with a musculoskeletal specialist.
  • If indicated, we will schedule your therapy at the Carrell Clinic in Dallas, TX. 
  • Dr. Bulger may prescribe a medication to put you at ease during the injection. Due to this potential use of a medication, we request that you receive a ride to and from the Carrell Clinic facility.
  • Your Stem cell injection will be administered under guided ultrasound with numbing cream applied to the injection site for your comfort.  
  • After the injection, we will follow up with you to gain your feedback regarding your experience and progress towards healing.

Regenerative medicine is gaining momentum as a revolutionary treatment for conditions including but not limited to degenerative disease, sports injuries, arthritis, and everyday wear and tear. There is still more to be learned to harness the amazing potential that these therapies can provide, but there is no denying the successful outcomes seen in many thousands of patients  to date. 

We take an honest look at a promising future for regenerative medicine. Dr. Bulger has done his due diligence in researching the science behind regenerative medicine, reviewing what is currently being offered and how these products are being marketed. We do not make any outlandish claims regarding the benefits, and we do everything we can to help set your body up for the procedure to be safe and successful.

There is evidence that stem cells are much more successful in an optimal environment. To set the stage for an optimal environment within your body, we focus on a healthy dietary program prior to your injection, and we monitor your prescriptions, along with dietary suggestions for the months following the procedure. Everything we do is with great thought and gives the patient the best chance for success, promoting the stem cells’ ability to heal.

  • Currently, the only FDA compliant regenerative medicine therapies include:
    • BMC: Cells retrieved from your own bone marrow.

Find out if DV360 is a good fit for you. Schedule a complimentary call.